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Low-dose naltrexone (LDN)

MedicationOff-label14 reviews
+1.6
Average score out of 5
Based on 14 experience(s)

Naltrexone is an opioid receptor antagonist. At low doses, it is used off-label for its immunomodulatory and anti-inflammatory effects, notably to reduce fatigue, pain and neuroinflammation in Long COVID.

Brand names
Naltrexone (préparation magistrale)
Information
Subcategory
opioid receptor antagonist
Evidence level
3/5
Evidence type
observational studies and case series
Score distribution
+5
1 (7%)
+3
6 (43%)
+1
4 (29%)
0
2 (14%)
Negative
1 (7%)
Practical information
Time to effect
1-2 months
Common dosage
4.5 ml
Reported side effects
Delusions (7%)insomnia (7%)hypertension (7%)stomach tightness/tension (7%)tinnitus (7%)
Latest reviews
F
Anonymous review-5
26-35 y.o. · 8/20/2026

Had to go to emergency room

F
Anonymous review+3
26-35 y.o. · 5/6/2026
?
Anonymous review+1
26-35 y.o. · 5/5/2026

Reduced overall pain symptoms

F
Anonymous review+1
36-45 y.o. · 5/5/2026
F
Anonymous review+1
36-45 y.o. · 5/5/2026
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