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Low-dose naltrexone (LDN)

MedicationOff-label13 reviews
+2.1
Average score out of 5
Based on 13 experience(s)

Naltrexone is an opioid receptor antagonist. At low doses, it is used off-label for its immunomodulatory and anti-inflammatory effects, notably to reduce fatigue, pain and neuroinflammation in Long COVID.

Brand names
Naltrexone (préparation magistrale)
Information
Subcategory
opioid receptor antagonist
Evidence level
3/5
Evidence type
observational studies and case series
Score distribution
+5
1 (8%)
+3
6 (46%)
+1
4 (31%)
0
2 (15%)
Negative
0 (0%)
Practical information
Time to effect
1-2 months
Common dosage
4.5 ml
Reported side effects
Mild headaches and nausea on intial onboarding (8%)resolved after a few doses (8%)Nausea and stomach issues every day. Disrupted sleep with each dose increase. (8%)Vivid dreams for the first two weeks. (8%)
Latest reviews
F
Anonymous review+3
26-35 y.o. · 5/6/2026
?
Anonymous review+1
26-35 y.o. · 5/5/2026

Reduced overall pain symptoms

F
Anonymous review+1
36-45 y.o. · 5/5/2026
F
Anonymous review+1
36-45 y.o. · 5/5/2026
F
Anonymous review0
46-55 y.o. · 5/4/2026

It didn’t seem to have any benefit but stopping it my stomach immediately felt better. Some reading suggested that this could be related to the filler in the capsules.

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