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Duloxetine

MedicationOff-label3 reviews
+4.3
Average score out of 5
Based on 3 experience(s)

An antidepressant used to treat neuropathic pain, anxiety, and depression. In the context of Long COVID, it is prescribed off-label to manage chronic pain, paresthesias, and associated depressive or anxiety symptoms.

Brand names
Cymbalta
Information
Subcategory
serotonin–norepinephrine reuptake inhibitor (SNRI)
Evidence level
3/5
Evidence type
Observational studies and use based on efficacy in similar chronic pain syndromes.
Score distribution
+5
2 (67%)
+3
1 (33%)
+1
0 (0%)
0
0 (0%)
Negative
0 (0%)
Most improved symptoms
Chronic fatigue
67%
Post-exertional malaise
67%
Insomnia
33%
Slow movement
33%
Muscle weakness
33%
Practical information
Time to effect
2 weeks
Reported side effects
Would highly recommend starting off on a low-dose and then working up to the higher dose twice a day. Other than the fatigue getting worse when initially getting the medication in your system (67%)there’s nothing else that I’ve had to deal with. (67%)Would highly recommend you start on a lower dose and work your way up to a higher dose twice a day because when the medication is building up in your system (33%)it will make your fatigue worse (33%)but then it practically goes away (33%)
Latest reviews
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Anonymous review+5
36-45 y.o. · 5/19/2026

I was originally on a dose of 20g-30mg to manage my depression but at the same time and did manage my fibromyalgia symptoms after getting Covid and my symptoms got so much worse, especially information. I am now on 60mg X2 a game and the only thing I would say is getting it into your system. The first week is very sluggish and you’re tired. It’s really hard to explain, but I usually like to take a low dose and ease up to a high dose from once a day to twice a day and then the higher doses. And I usually try to start on a long weekend. When I was just using it for a mental health, but now it’s a must have in my medications’.

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Anonymous review+3
36-45 y.o. · 5/19/2026

I was originally on a dose of 2g-30mg to manage my depression but at the same time and did manage my fibromyalgia symptoms after getting Covid and my symptoms got so much worse, especially information. I am now on 60mg X2 a game and the only thing I would say is getting it into your system. The first week is very sluggish and you’re tired. It’s really hard to explain, but I usually like to take a low dose and ease up to a high dose from once a day to twice a day and then the higher doses. And I usually try to start on a long weekend. When I was just using it for a mental health, but now it’s a must have in my medications’.

?
Anonymous review+5
36-45 y.o. · 5/19/2026

I was originally on a dose of 2g-30mg to manage my depression but at the same time and did manage my fibromyalgia symptoms after getting Covid and my symptoms got so much worse, especially information. I am now on 60mg X2 a game and the only thing I would say is getting it into your system. The first week is very sluggish and you’re tired. It’s really hard to explain, but I usually like to take a low dose and ease up to a high dose from once a day to twice a day and then the higher doses. And I usually try to start on a long weekend. When I was just using it for a mental health, but now it’s a must have in my medications’.

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