Duloxetine

An antidepressant used to treat neuropathic pain, anxiety, and depression. In the context of Long COVID, it is prescribed off-label to manage chronic pain, paresthesias, and associated depressive or anxiety symptoms.

Subcategory

serotonin–norepinephrine reuptake inhibitor (SNRI)

Evidence level

3/5

Evidence type

Observational studies and use based on efficacy in similar chronic pain syndromes.