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Caffeine

Supplement4 reviews
+1.8
Average score out of 5
Based on 4 experience(s)

Natural central nervous system stimulant and adenosine receptor antagonist. Sometimes used in low doses by Long COVID patients to reduce fatigue and brain fog, though it may worsen palpitations, insomnia, and dysautonomia/POTS symptoms.

Information
Subcategory
stimulant / methylxanthine
Evidence type
anecdotal
Score distribution
+5
0 (0%)
+3
2 (50%)
+1
1 (25%)
0
1 (25%)
Negative
0 (0%)
Reported side effects
Caffeine significantly worsens my headaches (25%)had little to no effect on PEM or chronic fatigue (25%)
Latest reviews
F
Anonymous review0
36-45 y.o. · 4/28/2026
M
Anonymous review+3
65+ · 4/24/2026
M
Anonymous review+1
65+ · 4/24/2026

drink a 500mL of dark-roast coffee in the evening to ease the end of the methylphenidate effect

M
Anonymous review+3
65+ · 4/24/2026
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