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Midodrine

MedicationOff-label1 review
+3
Average score out of 5
Based on 1 experience(s)

Midodrine is a peripheral alpha-1 adrenergic agonist that increases vascular tone, used to treat orthostatic hypotension. In Long COVID, it is used to manage dysautonomia symptoms, particularly postural orthostatic tachycardia syndrome (POTS).

Information
Subcategory
Alpha-1 adrenergic agonist
Evidence level
4/5
Evidence type
Observational studies and established use for dysautonomia
Score distribution
+5
0 (0%)
+3
1 (100%)
+1
0 (0%)
0
0 (0%)
Negative
0 (0%)
Practical information
Time to effect
< 1 week
Reported side effects
Chills (100%)
Latest reviews
M
Anonymous review+3
26-35 y.o. · 4/26/2026

I mostly take them to counteract the low blood pressure caused by betablockers, but it does also help with tachycardia when sitting up. It seems my heart doesn't need to work as hard to keep my blood flowing

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