A class of antidepressants used to treat depression and anxiety, but also neuropathic pain and fatigue, symptoms frequently reported in Long COVID.
Information
Subcategory
antidepressant
Evidence level
4/5
Evidence type
observational studies and off-label use based on efficacy for specific symptoms (pain, fatigue).
Treatment class
✓
Score distribution
+5
0 (0%)
+3
0 (0%)
+1
2 (50%)
0
1 (25%)
Negative
1 (25%)
Practical information
Time to effect
3 weeks
Reported side effects
I've been placed on any and all series ssnris antipsychotics etc just for having physical symptoms and dealing with being treated like I'm weak or making it up and even targeted because I'm sicker and I'm not the crazy one (25%)these people are insane to think I'd lie! (25%)Extremely difficult to taper off and stop. Took 6+ months to taper off. Physiological withdrawals at every stage. (25%)
Latest reviews
F
Anonymous review-5
36-45 y.o. · 5/16/2026
F
Anonymous review0
36-45 y.o. · 4/28/2026
F
Anonymous review+1
26-35 y.o. · 4/22/2026
F
Anonymous review+1
46-55 y.o. · 4/21/2026
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