← MyLongPath

Guanfacine

MedicationOff-label3 reviews
+1.7
Average score out of 5
Based on 3 experience(s)

Alpha-2A adrenergic agonist originally used for hypertension and ADHD, proposed off-label (often combined with N-acetylcysteine) to treat brain fog and cognitive dysfunction in Long COVID.

Brand names
IntunivTenexEstulic
Information
Subcategory
alpha-2 adrenergic agonist
Evidence level
2/5
Evidence type
preliminary case series
Score distribution
+5
0 (0%)
+3
1 (33%)
+1
2 (67%)
0
0 (0%)
Negative
0 (0%)
Most improved symptoms
Latest reviews
M
Anonymous review+3
18-25 y.o. · 4/29/2026
F
Anonymous review+1
26-35 y.o. · 4/22/2026
F
Anonymous review+1
46-55 y.o. · 4/21/2026
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