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Fludrocortisone

MedicationOff-label2 reviews
+3
Average score out of 5
Based on 2 experience(s)

Fludrocortisone is a mineralocorticoid used to treat adrenal insufficiency. In Long COVID, it is sometimes used off-label to manage orthostatic intolerance and POTS by expanding plasma volume.

Information
Subcategory
mineralocorticoid
Evidence level
3/5
Evidence type
observational studies and expert consensus (for POTS)
Score distribution
+5
0 (0%)
+3
2 (100%)
+1
0 (0%)
0
0 (0%)
Negative
0 (0%)
Most improved symptoms
Practical information
Time to effect
< 1 week
Reported side effects
Fluid retention (50%)
Latest reviews
F
Anonymous review+3
26-35 y.o. · 4/25/2026

Life changing. Getting the POTS under control with fludrocortisone saved my life

F
Anonymous review+3
65+ · 4/21/2026
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