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Low-dose aripiprazole

MedicationOff-label3 reviews
+0.7
Average score out of 5
Based on 3 experience(s)

An atypical antipsychotic used at very low doses (typically 0.25–2 mg) in Long COVID and ME/CFS, potentially improving brain fog and fatigue through dopaminergic modulation and neuro-inflammatory effects.

Information
Subcategory
atypical antipsychotic
Evidence level
2/5
Evidence type
case series and mechanistic hypotheses
Score distribution
+5
0 (0%)
+3
1 (33%)
+1
0 (0%)
0
1 (33%)
Negative
1 (33%)
Most improved symptoms
Practical information
Time to effect
< 1 week
Reported side effects
Nightmares (33%)auditory hallucinations (33%)
Latest reviews
F
Anonymous review-1
26-35 y.o. · 5/7/2026

I previously took this medication a few years ago for Tourette's and OCD and it was helpful, but since then I've suffered a TBI and that may have changed how the medication affects me.

F
Anonymous review0
36-45 y.o. · 4/25/2026
F
Anonymous review+3
36-45 y.o. · 4/24/2026
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